VDR Gene: Vitamin D Receptor

The VDR gene encodes the vitamin D receptor, a protein that allows cells to respond to vitamin D. Since vitamin D affects over 200 genes, VDR variants can influence multiple body systems including bone health, immune function, and mood.

What Does the VDR Gene Do?

The vitamin D receptor binds to active vitamin D (calcitriol) and then attaches to DNA, regulating the expression of genes involved in calcium absorption, immune response, cell growth, and inflammation.

Key VDR Variants

rs2228570 (FokI): Affects the length and activity of the VDR protein. The 'f' allele creates a longer, less active receptor.

rs1544410 (BsmI): Located in an intron but affects VDR mRNA stability and expression levels.

rs731236 (TaqI): Associated with bone mineral density and vitamin D status.

Health Impacts

• Vitamin D utilization efficiency
• Calcium absorption and bone health
• Immune system regulation
• Autoimmune disease susceptibility
• Mood and seasonal affective patterns

Evidence-Based Recommendations

• Test vitamin D levels (25-OH-D) regularly
• Some variants may require higher vitamin D intake
• Consider vitamin D3 with K2 for bone health
• Ensure adequate magnesium (needed for vitamin D activation)
• Sun exposure with appropriate skin protection

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